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These findings are further corroborated by experimental models that show increased NOX4 activity under oxidative stress conditions, including treatment with RAS-selective lethal small molecule 3 (RSL3) or erastin, which have been shown to enhance lipid peroxidation and subsequent cell death (111,112)

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J Natl Compr Canc Netw

Protocol [2] Rats: Serial dilutions of dihexa in 50% DMSO or water (for dilutions of 50 g/mL or less) are prepared from the stock used to dose the animals to be used for preparation of a standard curve