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This additional pathway is suggested to be secondary and found in tissues with lower cytochrome P450 activity, such as kidneys [9,40]

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It was evaluated in a randomized phase 2 trial involving older individuals who had experienced a fall due to reduced muscle strength.[69] In contrast to MYO-029, which was found to be safe but insufficiently effective in producing a robust increase in muscle mass,[70] landogrozumab effectively increased lean body mass and improved overall physical performance in a geriatric population with diminished muscle strength.[69] However, due to the high similarity between MSTN and GDF11, many anti-MSTN antibodies have been reported to also bind to GDF11, raising concerns about potential side effects resulting from GDF11 inhibition