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This might include temporary limits while you are recovering, or permanent limits on your work activities

Fatigue Fatigue is common during tirzepatide therapy , particularly during dose escalation and periods of rapid weight loss

Lazo M, Clark JM

However, with the exception of istradefylline, almost all of the other clinical trials with novel therapeutics have failed in recent years, including preladenant, vipadenant, and the nonxanthine SCH58261 [59,60]