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The therapeutic efficacy of passively targeted BRNPs dependent on the EPR effect is largely influenced by differences in the strength of the EPR effect exhibited within different tumors (225)

Yet, performing long-term toxicology studies and dietary intervention trials for each new nano-formulation is resource-intensive, and regulatory agencies have not fully standardized the requirements

After intake of Pycnogenol , a compartment-specific deconjugation of phase II metabolites has been observed in a human volunteer (see section 5.5 Distribution into saliva)

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