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However, to ensure maximum efficacy, we strongly advise refrigerating the vial as soon as you have the opportunity, and using an insulated bag and cold packs to help keep the medicine within the correct temperature range when refrigeration isnt available
Am J Nephrol 2017;46:213-221
However, evidence suggests that when considering tirzepatide vs semaglutide safety, tirzepatide is associated with a notably higher incidence of gastrointestinal adverse events, with approximately 79.8% of users experiencing these issues compared to 30.81% for semaglutide
Switching medications If semaglutide side effects remain unmanageable despite dose adjustments, switching to an alternative GLP-1 receptor agonist or to tirzepatide may be appropriate
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