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ORCID: Affiliation: 5 PeQuiM - Laboratory of Research in Medicinal Chemistry, Institute of Chemistry, Federal University of Alfenas, Alfenas 37133-840, MG, Brazil These authors contributed equally to this work

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5 Concluding remarks: a blurry view of fuzzy objects To sum up, the observations presented here clearly show that low-resolution techniques were crucial for assembly of information leading to the establishment of the field of protein intrinsic disorder