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Furthermore, growing evidence suggests that the dysbiosis of the gastrointestinal tract may eventually contribute to the impairment of intestinal mucosal integrity, instigate a high-level inflammation response, affect the bile acids cross-talk, and disrupt minerals absorption ratethereby, hastening the evolution of OP

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During the progression, asbestos can be recognized and taken up by macrophages, then stimulating the secretion of IL-1 family and the activation of NLRP3 inflammasomes, thus inducing inflammation