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It has been reported that an average of 630% of patients could show vitamin B12 deficiency due to metformin use.[] As per UK MHRA, decreased vitamin B12 levels, or vitamin B12 deficiency, are now considered to be a common side effect in patients on metformin treatment, especially in those receiving a higher dose or longer treatment duration and in those with existing risk factors

But total treatment time depends on many factors, including: Case complexity Tooth movement needed Bite correction Age Biology Elastics wear Oral hygiene Broken brackets Missed appointments It Does Not Replace the Orthodontists Skill Digital planning is powerful, but it is not the doctor

Tips : If you engage in regular physical activity, such as running, you may experience slight tenderness in the thighs after injection

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