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Description

It is therefore possible that high cholesterol might impact on the capacity of the GLP-1R to regulate mitochondrial and beta cell function via altered expression and interaction with cholesterol regulatory enzymes, hindering the insulin secretion potentiation effect of the receptor

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10.1016/j.mad.2006.11.016 Mech Ageing Dev

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The 0.25mg to 2.4mg titration schedule represents the optimal balance identified through these extensive research programs

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