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Protocol and registration This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (Moher et al., 2009) and the guidelines from the Cochrane Handbook for Systematic Reviews of Interventions (Higgins and Green, 2008)

Topical GHK-Cu generally has a good safety profile when used as directed

It is free of fragrances, parabens, and other harsh chemicals, making it suitable for various skin types, including sensitive skin