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TNF and its Receptors in AD Nevertheless, TNF- also amplifies inflammatory cascades by inducing other cytokines such as IL-1, IL-6, and IL-8, sustaining chronic neuroinflammation if not counterbalanced by anti-inflammatory mediators like IL-10 [61]

7173 While not yet identified in the mitochondria of skin cells, ER and ER are present in mitochondria elsewhere and through ER, estrogen stimulates manganese superoxide dismutase to reduce damage from reactive oxygen species that inhibits apoptosis

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Overcoming Challenges in Preclinical to Clinical Development The preclinical to clinical trial transition is fraught with potential pitfallsfrom gaps in data packages to manufacturing delays