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Low testosterone is especially common in men aged 35 and older, as testosterone levels naturally decline with age

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After three months of intragastric Dihexa administration (1.44 or 2.88 mg/kg), the APP/PS1 mice showed restored Morris water maze performance, increased neuronal cell counts and synaptophysin expression on Nissl staining, reduced microglial and astrocyte activation, decreased pro-inflammatory cytokines (IL-1, TNF-) and increased anti-inflammatory IL-10

During inflammation, immune cells are activated and migrate to the site of inflammation, causing the infiltration of various immune cells, such as lymphocytes, macrophages, and neutrophils, within a short period of time, further enhancing the unfolding of the inflammatory response (Coussens and Werb, 2002)