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Following additional investigation, it was found that the expression of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is concentration-dependently upregulated in quercetin-treated KATOIII/OXA cell lines, which blocked the phosphorylation of the PI3K/Akt signaling pathway, limited P-gp activity, and increased the intracellular level of oxaliplatin in KATOIII/OXA cells, thereby reversing oxaliplatin resistance (110)

Witard, Daniel Peckham, Theocharis Ispoglou, Ajay Pratap Singh PLOS ONE.2022