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In addition, insulin-like growth factor-1 (IGF-1) treatment can inhibit CSD and calcitonin-gene-related peptide (CGRP) production, thereby relieving migraine-related hyperalgesia [29]

A small percentage maintain loss through intensive lifestyle modification alone, but research shows fewer than 10-15% sustain clinically significant weight loss without medication long-term

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[DOI] [PubMed] [Google Scholar] 67.McGuire D.K., Marx N., Mulvagh S.L., Deanfield J.E., Inzucchi S.E., Pop-Busui R., Mann J.F.E., Emerson S.S., Poulter N.R., Engelmann M.D.M., et al