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Time to Results: Noticeable Appetite Reduction: GLP-1s (semaglutide, tirzepatide): 1-2 weeks Phentermine: 1-3 days Phentermine-topiramate: 1-2 weeks Naltrexone-bupropion: 4-8 weeks Orlistat: Doesnt reduce appetite Measurable Weight Loss: Tirzepatide: 5-8% by week 20, 15-22% by week 72 Semaglutide: 5-7% by week 20, 10-15% by week 68 Phentermine-topiramate: 5-6% by week 28 Others: 3-5% by week 24-28 GLP-1s produce steady, sustained weight loss over 16-20 months
Endoscopy data also support concern for retained gastric contents
Thus, it is important to have a low threshold of suspicion for PBH and provide early diagnosis and management in this patient population
Its built on clinically backed botanicals like Cissus quadrangularis, Eriocitrin (from citrus extracts), and Cinnamon extract all known to support natural GLP-1 release
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