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Many patients find they are able to make healthier choices, feel more satisfied with smaller portions, and achieve sustainable weight loss with the support of a structured medical program

Concurrently, SFN has been shown to improve anxiety and depression symptoms in mice by activating the Nrf2/ heme oxygenase-1 (HO-1) signaling pathway (Ferreira-Chamorro et al., 2018) and inhibiting the hypothalamicpituitaryadrenal (HPA) axis and stress response (Wu et al., 2016)

Chronic stress and the resulting hyperactivation of the HPA axis can lead to increased production of pro-inflammatory cytokines, which are known to disrupt neurotransmitter systems, impair neuroplasticity, and ultimately lead to mood dysregulation [80]

For example, Enterococcus faecalis produces extracellular superoxide (O2) and H2O2, and was shown to cause intestinal epithelial cell death (34)