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In the Look AHEAD study, which examined the effect of intensive lifestyle intervention in patients with obesity and type 2 diabetes, the composite endpoint of adverse cardiovascular events and mortality was reduced by approximately 20% over a median follow-up period of 10.2 years, only in the group of patients that achieved a weight loss of 10% or more from their initial body weight (about 40% of the intervention arm) [7, 8]

Additionally, there is no evidence that hyperthyroidism reduces the effectiveness of semaglutide or other GLP-1 receptor agonists for their intended uses, Dr

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