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Unlike semaglutide, which activates only the GLP-1 receptor, or tirzepatide, which targets both GLP-1 and GIP, retatrutide engages three key metabolic receptors simultaneously: GLP-1 receptor curbs appetite, slows gastric emptying, and lowers blood sugar

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Some patients feel completely unaffected cognitively, while others describe a 23 week period of reduced mental clarity that gradually resolves as their body adapts