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A oligomers exacerbate this process, producing reactive aldehydes like 4-hydroxy-2-nonenal (HNE) that damage proteins and contribute to neurodegeneration [172]
Piperlongumine (PL), an oxidative stress inducer, inhibits ZIKV replication in various cells, including the human brain microvascular, Vero, and human umbilical vein endothelial cells 129
Over the 12-week intervention, there was also a ~5kg reduction in body mass, in which 3.5kg was fat, with a 1.1kg loss in lean mass
Whereas the putative mechanism of action of IV vitamin C as an ESA adjuvant is an increase in the release of iron from ferritin and the reticuloendothelial system and increased iron utilization during heme synthesis, none of the studies reviewed showed reduced utilization of administered iron therapy
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