constipation with semaglutide can cause severe 🫠 Semaglutides aka Wegovy and Ozempic are becoming ever more popular Managing Constipation While Using Semaglutide

The clinical manifestations and severity of ileus present as: Complete inability to pass gas or have bowel movements, distinguishing it from simple constipation Severe abdominal distension causing visible swelling and extreme discomfort Intractable nausea and vomiting, including feculent vomiting in advanced cases Severe cramping and abdominal pain that worsens with attempted eating Dehydration and electrolyte imbalances from inability to absorb fluids Risk of intestinal perforation if pressure builds excessively Potential progression to sepsis and multi-organ failure without prompt treatment Need for nasogastric decompression, bowel rest, and potential surgical intervention The mechanism by which Ozempic causes ileus directly relates to its intended therapeutic action of slowing gastrointestinal motility, but in susceptible individuals, this effect becomes pathologically exaggerated

Both arms had appropriate dose escalation to usual max dosages as once-weekly SubQ injections for 16 months resulting in an average of 20% weight loss for tirzepatide and 14% for semaglutide

Jena Shaw Tronieri, senior research investigator at the University of Pennsylvanias Center for Weight and Eating Disorders and co-author of the study

It is crucial to emphasize that such dosage recommendations are not grounded in scientifically validated evidence and should be approached with caution