Drug-induced acute liver failure is a fatal disease thats caused by the toxic metabolite N-acetyl-p-benzoquinone-imine that leads to glutathione depletion
Mel has been shown to regulate multiple molecular pathways, including inflammation, oxidative stress, apoptosis, and autophagy, under various pathophysiological conditions.32 Cas-3 is the most critical executioner in the caspase family and represents the final common substrate of both intrinsic and extrinsic apoptotic pathways.32 Once activated, Cas-3 cleaves this substrate, thereby reflecting the progression of apoptosis.33 In the present study, CARB treatment appeared to initiate this process in ovarian tissue, as evidenced by intense Cas-3 immunoreactivity
Berger, AC, Korkut, A, Kanchi, RS, Hegde, A, Lenoir, W, Liu, W, Liu, Y, Uppore Kukkillaya, AR, Li, X, Sood, AK, Lazar, A, Baggerly, KA, Roszik, J, Zhang, W, Akbani, R, Broom, BM, Ju, Z, Li, J, Liang, H, Ling, S, Lu, Y, Mills, GB, Weinstein, JN, Zhang, J, Liu, X, Wang, L , Carvalho, AL, Fregnani, JG, Reis, RV, Scapulatempo, CN, Ajani, JA, Behrens, MC, Bondaruk, J, Broaddus, R, Czerniak, BA, Esmaeli, B, Fujimoto, J, Gershenwald, JE, Guo, CC, Logothetis, CJ, Meric-Bernstam, F, Moran, C, Ramondetta, LM, Rice, DC, Tamboli, P, Thompson, T, Troncoso, P, Tsao, A, Wistuba, II, von Deimling, A
Unlike eryptosis phenotypic assays, parasite growth assays are conducted over 72 h, and therefore require Albumax supplementation to allow parasite survival
