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GLP-1RAs in the cardiovascular system In the cardiovascular system, GLP-1 can reduce cardiac ischemia-reperfusion injury through the activation of specific signaling pathways, such as the PI3K/Akt pathway

10.1016/j.jep.2015.04.030 152 ZhaoZ.WangW.WangF.ZhaoK.HanY.XuW.et al (2009)

The Limitations You Should Know: Dependency, Cost, and Side Effects Despite benefits, GLP-1 medications present challenges such as dependency, rebound weight gain upon stopping treatments, high costs especially in emerging markets, and side effects like nausea or digestive discomfort

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