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T2DM and hyperglycemia are also associated with oxidative stress from the overproduction of reactive oxygen species (ROS) and decreased efficiency of scavengers systems ( Furthermore, our lab has previously shown that individuals with T2DM have lowered levels of GSH due to decreased levels of both GCL and GSS protein compared to healthy subjects ( M

SLU-PP-332 activates ERR, ERR, and ERR receptors which co-activate PGC-1, the master regulator of mitochondrial biogenesis, triggering exercise-like transcriptional responses in muscle tissue without physical activity

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