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The volume of saline added the dilution directly affects how the toxin behaves: Concentrated reconstitution (lower saline volume) smaller injection volume, less diffusion, more precise effect, but requires more accurate placement Dilute reconstitution (higher saline volume) larger injection volume, more diffusion, easier to inject but more risk of toxin spreading to unintended muscles We use a standard reconstitution of 100 units in 2.5ml of unpreserved saline a precise concentration that gives accurate dosing without excessive diffusion

This potentially implies that truncal fat mass may be pathogenic in IIH

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Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency