Elevated ROS levels or reduced antioxidant defenses lead to oxidative stress which results in damage to biomolecules such as proteins, lipids, carbohydrates, and nucleic acids [65, 66]
Lactobacillus acidophilus
Research showed that the drug significantly reduced the abundance of multiple opportunistic pathogenic bacteria, such as the Enterobacteriaceae , Staphylococcaceae and Veillonella genera, and increased the abundance of the Anaeroplasma genus, which shows the potential of Chaihu-Shugan Power targeting gut microbiota dysbiosis during the treatment of AILD ( Lactobacillus and Bifidobacterium and decreased Streptococcus , Escherich ia coli-Shigella , Veillonella and Enterococcus in rats, suggesting that GS extract may be a promising AILD therapeutic drug by balancing the structure and diversity of gut microbiota ( Presently, research on gut microbiota-focused AILD treatment has progressed but has mainly concentrated on the exploration of antibiotic applications
Additionally, the high cost of therapy and inconsistent insurance coverage-particularly in low- and middle-income countries-pose significant barriers to market penetration, highlighting the need for more affordable and widely accessible treatment options
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