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479 Another cascade linking astrocytes to the pathophysiology of Down syndrome is an increased production of hydrogen sulphide, which is catalysed by cystathionine--synthase expressed, more or less exclusively, in astrocytes, and upregulated in a rat model of the disease

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Additionally, the variation in response of patients makes it difficult to compare the glucose lowering effects of different hypoglycemic drugs except in direct head-to-head comparison studies