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Although the structure of the intestinal microbiota is very complex and the experimental design varies among studies, such as the different timing of HFD induction, distinctions in the duration of metformin treatment, and variations in mouse strains, but the impact of metformin on gut microbiota derived from these studies are nearly consistent
A reasonable hypothesis is that the rapid cycling allows the liver to respond quickly to the glutathione requirements of other tissues
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It is an alteration in the balance of prooxidant /antioxidant system in favour of prooxidant with attendant lethal effects with resultant damage to the cellular macromolecules (Fig
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