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Although the inhibition of CA9 did not affect the basal level of glycolysis, it significantly inhibited the gemcitabine-induced acceleration of extracellular acidification and mitochondrial functions in cancer cells, which was verified in xenografted mice

Consuming 20 mg/kg generally produces milder effects, while bumping the dose up to 50 mg/kg results in more pronounced effects and side effects

437,439 A single non-randomized, unblinded study indicated that a regimen of 10 mg short-acting initially, followed by 20 mg slow-release every 6 h, could be effective when oxygen or descent was unavailable

One-factor analysis of variance (ANOVA) was carried out using the SPSS 15.0 software (SPSS Inc., Chicago, IL)