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Toxic solvent residues DMF (dimethylformamide) Known liver toxin Associated with reproductive toxicity Must be removed to extremely low limits in GMP drugs DCM (dichloromethane / methylene chloride) Probable human carcinogen Central nervous system depressant Dangerous even in small amounts if injected TFA (trifluoroacetic acid) Corrosive Can remain in peptides as unmeasured TFA salt Pharmaceutical products often convert TFA salts to safer counterions Without validated HPLC, mass spectrometry, and residual solvent testing, patients may be injected with harmful chemical contaminants

Say the patient was going on holiday on the Monday, then why would giving the patient it a day early (from a day they are not open) be any strain on resources as the patient is not going to book another appointment on the Monday

Vitamin D deficiency is common, in part because people who are sick tend to stay at home and not get enough sunshine