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It was in conjunction with the previous findings that treatment with LA (50mg/kg) could suppress UUO-induced tubular interstitial fibrosis in mice by ameliorating the epithelial mesenchymal transition (Hyun et al., 2016)

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In pathologic conditions, the loss of HS disrupts the charge selectivity of the glomerular filtration barrier, which increases the filtration of proteins and leads to proteinuria (97)

And critically for obesity research, it acts centrally: amylin binds to receptors in the area postrema and the brainstem, where it generates satiety signals that communicate to the brain that the body has had enough to eat