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As early as 1998, cytochrome P450 was introduced within HSV-I, enabling conversion processes whereby cyclophosphamide becomes activated specifically inside malignant tissues, leading toward notable anticancer effects evidenced across medulloblastoma atypical teratoid/rhabdomyosarcoma brain neoplasms among others ( An additional strategy involves inserting a gene-encoding yeast cytosine deaminase/uracil phospho-ribosyltransferase fusion(Fcy::Fur) into HSV-I, prompting infected neoplastic entities capable of synthesizing said construct

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Micronized progesterone is generally preferred over synthetic progestins due to a more favorable cardiovascular and neurocognitive profile

Flemetakis, E., & Labrou, N