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doi:10.3945/jn.108.102475

Myint AM, Kim YK, Verkerk R, Scharp S, Steinbusch H, Leonard B

Subcutaneous B12 shots tend to be less painful because the needle is not inserted deeply

Why this matters (and dont underestimate it): ~20% weight loss in non-diabetic obesity (REDEFINE-1) 1416% weight loss in T2D (REDEFINE-2) Dual mechanism = appetite suppression + satiety reinforcement Designed for long-term maintenance, not just short-term loss Potentially better GI tolerability with flexible titration This isnt another GLP-1. Its a clear signal that amylin is emerging as a serious second pillar in next-gen obesity care