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Genetics of depression: progress at last

In a recent study by Dr

Given that ketamine augmented NOX expression in the mouse brain, and that both apocynin (an inhibitor of NOX activity) pretreatment and NOX deficiency prevented ROS generation and the decrease of PV expressing interneurons, NOX activation was indicated as a major contributor to the pathogenesis of ketamine-induced psychosis and possibly also to schizophrenia (Behrens et al