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On one hand, SCFAs (especially butyrate) strengthen the gut barrier and have anti-inflammatory effects that indirectly protect the BBB [75]

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This dosing regimen also resulted in effects on growth, with the animals failing to gain weight.31 Both of these effects were prevented by the administration of methionine in the diet leading to the suggestion that both the 5-oxoprolinuria and growth inhibition resulted from a lack of sulfur-containing amino acids due to GSH consumption to detoxify NAPQI, with severe disruption of the gamma -glutamyl cycle