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Retatrutide and Heart Issues: Cardiovascular Effects, Risks, and Safety Retatrutide and heart issues are a growing focus of clinical interest as this investigational triple agonist advances through trials for obesity and type 2 diabetes

A post-hoc subgroup analysis of that trial suggested benefit of prasinezumab in subjects with faster progression [209] and a comparison of MDS-UPDRS progression during the 4-year open-label extension phase with historical controls showed divergent trajectories in favour of prasinezumab from year 2 of treatment onwards [210]

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