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Prolonged diagnostic pathways may also contribute to disease progression, including the development of deep infiltrating disease and adhesions, which can complicate treatment and reduce reproductive outcomes

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Minority populations are particularly affected, with half or more of newly diagnosed cases of type 2 diabetes in childhood and adolescence occurring in Hispanic, non-Hispanic Black, Asian/Pacific Islander and American Indian populations [268]

Overall, nutraceuticals and targeted vitamin/mineral supplementation are viewed as strategies that can provide modest benefits with minimal adverse effects in managing various ASD symptoms