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doi:10.1016/j.ejphar.2015.03.011 Rossini M, Di Munno O, Valentini G, Bianchi G, Biasi G, Cacace E, Malesci D, La Montagna G, Viapiana O, Adami S (2007) Double-blind, multicenter trial comparing acetyl l-carnitine with placebo in the treatment of fibromyalgia patients

J Am Coll Nutr (2018) 37(6):47986

Common reasons patients ask about split dosing include: Nausea after injections Bloating or reflux Severe appetite suppression Fatigue after injections Medication wearing off late in the week Fluctuating hunger levels Difficulty eating enough protein Trouble maintaining hydration For some patients, smaller divided doses may create more stable medication exposure throughout the week