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10.4 Ocular delivery barriers and potential side effects The bloodretinal barrier, composed of tight junctions in retinal vascular endothelial cells and the RPE, hinders the penetration of macromolecular drugs (such as iron chelators) into the posterior segment of the eye (181)

It may be considered only as a last-resort option for severe, sleep-disrupting cramps after careful riskbenefit assessment

It activates the natural growth hormone secretagogue receptor (GHSR) in the brain, which is the same receptor that ghrelin binds to