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The mechanisms of HIF-1a involved in acute hypobaric hypoxia include the ROS pathway, the Toll-like receptor 4 (TLR4) signaling pathway, and the autophagy pathway ( With its multi-compounds and multi-target properties, traditional Chinese medicine (TCM) has been widely used as an alternative medical treatment for various diseases (Li et al., 2020b)

The 12-week double-blind phase was followed by a 40-week open-label dose titration phase, where all patients (n=173) received 5 mg, 10 mg or 20 mg rosuvastatin daily

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How does GHK-Cu interact with retinoids