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However, previous studies have found that DPP-4 can be regulated by inflammatory factors such as signal transducer and activator of transcription 1 (STAT1), hepatocyte nuclear factor-1 (HNF-1), interleukin-12 (IL-12), and tumor necrosis factor- (TNF-) [33,34,35]

The secondary fluorescent antibody was then incubated in the dark, and the cell nucleus was counterstained with DAPI

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However, due to the lentiginous growth pattern, multifocal nature of MM, and limitations of the specific MM anatomic sites, it is extremely difficult for surgery to achieve wide negative margins, which leads to a high local relapse rate at 50%-90% (136)