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In a study on semaglutide involving non-diabetics, after 38 weeks, some participants experienced significant swings back towards their baseline BMI or even higher than their starting point

Therefore, basic and clinical trials further reveal the mechanism of GLP-1 on lipid metabolism, which is helpful to improve our understanding of GLP-1 function and is essential for advancing its clinical application

Oral Herbal Supplements (Berberine, etc.): These are dietary supplements taken orally that have some published research on metabolic effects