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Hawiger is also a professor of Molecular Physiology and Biophysics at Vanderbilt, and a Health Research Scientist at the Nashville Veterans Affairs Medical Center

There are five different transcription factors under this family that get activated in the presence of pro-inflammatory cytokines, leading to the translocation of P65/P50 dimers stored in the cytoplasm to the nucleus activating cognate B motif, resulting in the expression of the NF-B target gene under the canonical pathway which has been extensively studied than noncanonical pathway activated by tumor necrosis factor (Motolani et al., 2021)

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Although clinical studies remain limited for most substances, early results showing reductions in cravings, substance use, and other related outcomes are encouraging