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Questi sistemi sono rappresentati essenzialmente da molecole, in particolare di una sostanza definita con lacronimo ATP (adenosina trifosfato)

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In the brain, preproglucagon expressing neurons are localized to the brainstem in regions including the nucleus of the solitary tract (NTS) and ventrolateral medulla (Merchenthaler et al., 1999) and these neurons produce a number of peptides including GLP-1, oxyntomodulin, and glucagon-like peptide-2 (Holst, 1999

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