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Similar reductions in IL-1 and TNF- were also observed after administering other polyphenols, including gallic acid (GA) at 100 mg/kg, for 112 days [20], chlorogenic acid (CGA) (80 mg/kg, p.o., for 16 weeks) [23], sesamol (100 mg/kg, p.o., for 8 weeks and 0.05% w/v, in drinking water, for 10 weeks) [24, 36], Nano-Honokiol (20 mg/kg, p.o., for 17 weeks) [27], quercetin-3-O-glucuronide (Q3G) (50 mg/kg, p.o., for 4 weeks) [33], and blueberrymulberry extract (BME) (300 mg/kg, p.o., for 6 weeks) [40]

Vitamin B12 is an essential nutrient that plays a critical role in the production of red blood cells, the maintenance of the nervous system and DNA synthesis