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The time of bolus injection may be adapted to the actual time of the start of intake, and the rapid-acting insulin dose may also be adapted to the composition of each meal.15 Premixed insulinsIntroduction Premixed insulins are a fixed combination of an intermediate-acting insulin with regular insulin or with a rapid-acting analogue.19,20 They are usually administered twice daily, before breakfast and supper, but may be administered at the three main meals