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The lyophilization (freeze-drying) process removes all the water, leaving behind a very small, compact puck or even just a light film of white powder at the bottom of the vial

The aforementioned drastic increase in GLP-1 use comes as a result of increased accessibility through recent years of FDA policy expansion regarding permissibility of compounding pharmacies

The 48-week retatrutide curve had not plateaued at readout, so the 24.2% figure likely under-represents the 72-week steady state that would match SURMOUNT-1's window [1]

Compounded tirzepatide is made in response to FDA-recognized shortages of the commercially available drug