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EClinicalMedicine , 54

We examined MCs in the brain of human stroke patients, investigated MCs in mice after stroke by flow cytometry, administered a MC stabilizer to aged mice and measured plasma histamine, MCs and cytokines in mice and stroke patients

Altogether, astrocytic purinergic receptors represent attractive therapeutic targets due to their early involvement in disease pathogenesis and in regulating key processes such as inflammation, neuronal excitability, and interstitial solute clearance