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Additionally, subgroup analyses were performed to examine study design (case-control or cohort), location (by continent), sample size (by quartile), quality (NOS score high, medium, or low), adjustment for confounders (yes/no), timing of maternal smoking assessment (prenatal visit, at birth, after birth), and method of ascertaining ASD diagnosis (direct evaluation, medical or developmental record, parental report)

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Over time, this damage can lead to difficulty breathing

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