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This guidance is based on the Public Health Service-sponsored Clinical Practice Guideline, Treating Tobacco Use and Dependence: 2008 Update. As of January 1, 2020, 16 states (Colorado, Delaware, Illinois, Kentucky, Louisiana, Maryland, Massachusetts, New Jersey, New Mexico, New York, North Dakota, Oregon, Pennsylvania, Rhode Island, Utah, and Vermont) have laws or regulations in place requiring at least some private insurance plans to cover certain cessation treatments

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This later effect correlated with reduced proliferation in response to the mitogenic stimulus and increased cell apoptosis (186)