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Since acute exposure to non-flavored electronic cigarette aerosol was also shown to activate TRPA1 receptors in endothelial cells, this suggests that combined effects of propylene glycol and vanilla chemical flavorant may potentiate the adverse effect of each other or may exert greater side effects in vivo (105)

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The Tobacco Control Act, as described above, gives the FDA authority to regulate manufacture, distribution, and marketing of tobacco products including e-cigarettes, but it cannot ban face-to-face sales in a particular category of retail outlets. Johanna Kreafle, M.D

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